This article was review by Thomas Cooper, MD from Baylor College of Medicine. Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global ...

Proteoforms, the diverse molecular variants of proteins, are key to understanding cellular functions, disease mechanisms, and ...

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs -- single-stranded RNAs involved in protein synthesis -- and proteins from the same stretch of DNA, ...

Genes contain the essential building instructions for life, guiding cells on which amino acids to assemble in what sequence to produce specific proteins. The human genome codes for about 20,000 such ...

USP39 stabilizes the spliceosome (green), which cuts out unneeded parts (grey and purple) of the mRNA. If USP39 is missing, some of the mRNA is poorly processed. This results in misfolded proteins, ...

What kills most people who die from cancer is not the initial tumor. It’s the intolerable disease burden on the body that arises when tumor cells continually expand their numbers after spreading to ...

A study at the University of Cologne's CECAD Cluster of Excellence in Aging Research has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that ...

Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor, new research finds. The interrupted non-coding regions in pre-mRNAs, termed ...

Pediatric acute myeloid leukemia (AML) is one of the most common acute leukemias in children. While treatment outcomes have improved in recent years, approximately 30% of patients relapse following ...

Protein-coding genes carry the blueprint for protein production. In higher organisms, however, most of the coding-gene transcripts, or pre-mRNAs, are separated by non-coding sequences called "introns, ...