The splicing of nuclear pre-mRNA is a fundamental process for the expression of most metazoan genes. More than half of reported exonic mutations in human disease and cancers are due to ...

RIVERSIDE, Calif. -- Alternative splicing, a clever way a cell generates many different variations of messenger RNAs — single-stranded RNAs involved in protein synthesis — and proteins from the same ...

Alternative splicing (AS) is a key technique for increasing transcriptome and proteomic diversity from a small genome. Almost all human gene transcripts are alternatively spliced, resulting in protein ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts. RNA splicing is a cellular process ...

Cold Spring Harbor, NY - No one knows how many times in a day, or even an hour, the trillions of cells in our body need to make proteins. But we do know that it's going on all the time, on a massive ...

What are the mechanisms of alternative splicing? Prior to RNA splicing, RNA polymerase II produces pre-mRNA transcripts by transcribing gene sequences into a collection of non-coding introns and ...